Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
作者： Joseph Glenn , Wenyu Zhu , James D. Rodgers
DOI:
关键词:
摘要: The present invention provides heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines of Formula I: wherein X, Y, Z, L, A, R5, n, m, r are defined above, as well their compositions methods use, that modulate the activity Janus kinases (JAKs) useful in treatment diseases related to JAKs including, for example, inflammatory disorders, autoimmune cancer, other diseases.
google.it 参考文章(455)
Louis Storace, Stacey Shepard, Maria Rafalski, James D. Rodgers, Argyrios G. Arvanitis, Ravi Kumar Jalluri, Thomas P. Maduskuie, Nikoo Falahatpisheh, Haisheng Wang, Pyrazolyl substituted pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors ,(2008)
Giovanni Palombi, Marco Farina, Jean-Philippe Rocher, Stefania Gagliardi, Emmanuel Le Poul, Novel Heterocyclic Compounds as Positive Allosteric Modulators of Metabotropic Glutamate Receptors ,(2006)
Adolph C. Bohnstedt, Michael J. Ohlmeyer, Celia Kingsbury, Koc-Kan Ho, Jorge Gabriel Quintero, Ming You, Haengsoon Park, Yingchun Lu, Purine and imidazopyridine derivatives for immunosuppression ,(2006)
Paul Steven Changelian, Method of treatment of transplant rejection ,(2003)
Hosheng Tu, Hsing-Wen Sung, Drug-loaded biological material chemically treated with genipin ,(2003)
Sergey Alexeevich Zozulya, Douglas Eric Mcgrath, Cell-free protein expression systems and methods of use thereof ,(2006)
Timothy Gahman, Anthony Pinkerton, Robert Davis, J. Semple, Inhibitors of MAPK/Erk Kinase ,(2006)
Peter Michael Wovkulich, Kin-Chun Luk, Kshitij Chhabilbhai Thakkar, Giacomo Pizzolato, Jin-Jun Liu, Zhuming Zhang, Yi Ren, 7,8-Disubstituted pyrazolobenzodiazepines ,(2005)
Shigeki Kunikawa, Koichiro Mukoyoshi, Shohei Shirakami, Keiko Hatanaka, Yutaka Nakajima, Yasuyuki Higashi, Takayuki Inoue, Hiroshi Sasaki, Fumie Takahashi, Akira Tanaka, Hisao Hamaguchi, Kazuo Nakai, Heterocyclic janus kinase 3 inhibitors ,(2006)
Michele Sanicola-Nadel, Leona E. Ling, Angiogenesis-modulating compositions and uses ,(2001)