Therapeutically useful molecules
作者： Hans Josef Stauss , Liquan Gao , Shao-An Xue
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摘要: A T cell receptor molecule (TCR) containing an alpha chain portion and a beta wherein the contains three complementarity determining regions (CDRs): CDR1α: SSYSPS CDR2α: YTSAATL CDR3α: VVSPF-SGGGADGLT or comprising consisting of SPFSGGGADGLT CDR1β: DFQATT CDR2β: SNEGSKA CDR3β: SARDGGEG RDGGEGSETQY, up to amino acid residues in one more CDRs are replaced by another residue. The invention also includes polynucleotides encoding TCR molecules, host cells said polynucleotides. Patient derived may have molecules introduced therein, engineered be into patient order combat WT1-expressing malignancy.
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