An essential role for the immune system in the mechanism of tumor regression following targeted oncogene inactivation

摘要: Tumors are genetically complex and can have a multitude of mutations. Consequently, it is surprising that the suppression single oncogene result in rapid sustained tumor regression, illustrating concept cancers often "oncogene addicted." The mechanism addiction has been presumed to be largely cell autonomous as consequence restoration normal physiological programs induce proliferative arrest, apoptosis, differentiation, and/or cellular senescence. Interestingly, recently become apparent upon inactivation, immune response critical mediating phenotypic consequences addiction. In particular, CD4(+) T cells suggested essential remodeling microenvironment, including shutdown host angiogenesis induction senescence tumor. However, adaptive innate likely involved. Thus, effectors system involved not only initiation, progression, immunosurveillance, but also regression targeted inactivation. Hence, inactivation may an effective therapeutic approach because both reverses neoplastic state within cancer reactivates remodels microenvironment.