Antibiotic prophylaxis during clean neurosurgery: a large, multicenter study using cefuroxime

摘要: Abstract Cefuroxime is a second-generation cephalosporin with in vitro activity against the organisms that are commonly associated neurosurgical wound infections. Other properties of cefuroxime an elimination half-life 1.3 hours, which yields prolonged serum concentrations, and its ability to penetrate blood-brain barrier proportion degree inflammation. A prospective, multicenter, open-label study was conducted evaluate efficacy safety for antibiotic prophylaxis patients undergoing clean neurosurgery. 1.5 g given intravenously 25 60 minutes before surgery; procedures lasting more than 3 750 mg 8 hours after initial dose. Patients were examined surgery, daily during hospitalization, at weeks surgery. total 956 adults enrolled study. The most common laminectomy (41.8% patients) or craniotomy (24.3%), mean duration surgery 3.2 hours. Infection occurred 2 (0.3%) 592 assessable by time discharge 1 additional patient 8-week follow-up evaluation (0.5%) 560 patients. Drug-related adverse events 5 These results indicate low incidence postoperative would infection well tolerated