DNA damage is increased in lymphocytes of patients with metabolic syndrome.
作者： Ali Karaman , Hatip Aydın , Bilge Geçkinli , Arda Çetinkaya , Selin Karaman
DOI: 10.1016/J.MRGENTOX.2015.03.009
关键词:
摘要: We assessed DNA damage in patients with metabolic syndrome (MetS) by performing comet and micronucleus (MN) assays on peripheral blood lymphocyte cultures from study participants. 52 MetS 35 age-matched healthy controls were evaluated for abdominal obesity, body-mass index (BMI), pressure, serum triglycerides, HbA1c, HDL-C, fasting glucose levels. In addition, malondialdehyde (MDA) levels activities of superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) determined. Serum waist circumference, systolic diastolic BMI the subjects group significantly higher than those control (for each, p<0.001). However, mean level HDL-C was lower (p<0.001). study, length tails (10.23±1.98, range 5.72-15.08) (3.12±1.73, 0.6-7.1) MN frequency also increased (3.68±1.27 per 1000 cells) compared to that (1.81±0.84 Micronucleated cell comet-tail showed positive correlations BMI, plasma triglyceride (p<0.01) negative (p<0.01). Among oxidative stress factors, MDA controls. SOD GSH-Px enzyme These findings suggest have stress.
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