Related functional domains in virus DNA polymerases.

摘要: Analysis of the lesions in several drug-resistant DNA polymerase mutants herpes simplex virus along with comparative analysis published sequences other human herpesviruses has shown that most (five out six) are substitutions at amino acid residues conserved all four polymerases. Furthermore, majority regions polypeptide where there marked clusterings residues. On basis these data we have identified domains within which believe may important functional roles action enzyme. The apparent restriction potential sites conferring drug resistance explain difficulty selecting such using acyclovir (ACV) culture and their failure to emerge so far during ACV therapy. Extension polymerases adenovirus type 2, vaccinia phage phi 29 suggests enzymes also possess homologous those (regions I-III) a similar linear spatial distribution on polypeptides. results discussed relation known function