摘要: DNA replication is arguably the most fundamental of biological processes and serves as a pivotal element in poxvirus life cycle. Replication generates progeny genomes initiates transition to late gene expression. Unraveling mechanism identifying panoply enzymatic activities which it requires has been focus much recent research. The intent this chapter move beyond previous reviews (McFadden Dales 1982; Holowczak 1983) on viral proteins whose participation presumed basis genetic or biochemical data. Implicit discussion was choice broad definition replication, one centers synthesis but also encompasses regulation topology genomic its assembly into nucleoprotein complex.
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