Effects of inbreeding, endogamy, genetic admixture, and outbreeding on human health: a (1001 Dalmatians) study.

摘要: Aim “1001 Dalmatians” research program collects biomedical information from multiple small isolated populations (“metapopulation”) on Adriatic islands, Croatia, and investigates health effects of human population isola tion, inbreeding, admixture, outbreeding. Methods We collected random samples 100 individuals 9 island settlements an additional sample 101 immigrants to the pooled all study populations. According their personal genetic his tories, examinees were categorized as inbred, autochthonous, admixed, outbred. A total 76 inbred a 1001 matched out bred controls by gender, age (±5 years), village residence, education, socio-economic status. investigated presumed individual genome-wide heterozygosity predicted histories following 10 traits: systolic diastolic blood pressure, body mass in dex, high low density lipoproteins cholesterol, triglycerides, uric acid, creatinine, glucose. Results Personal history significantly affected pressure (Spearman ρ=0.157, P = 0.006), while effect cholesterol (ρ=0.105, 0.069), lipoprotein (ρ=0.104, 0.071) was suggestive. Admixed consistently showed values associated with lower risk. When autochthonous merged compared admixed outbred increase power study, three traits above also index became statistically significant. The medians for medically relevant group, genomewide heterozygosity, less favorable terms health.