The tick salivary protein, Salp15, inhibits the development of experimental asthma.

摘要: Activation of Th2 CD4(+) T cells is necessary and sufficient to elicit allergic airway disease, a mouse model with many features human asthma. Effectively controlling the activities these could be panacea for asthma therapy. Blood-feeding parasites have devised remarkable strategies effectively evade immune response. For example, ticks such as Ixodes scapularis, which must remain on host up 7 days feed repletion, secrete immunosuppressive proteins. Included among proteins 15-kDa salivary protein Salp15, inhibits cell activation IL-2 production. Our objective studies was evaluate inhibitory properties Salp15 in BALB/cJ mice were Ag sensitized by i.p. injection OVA aluminum hydroxide, or without 50 mug 0 7. All challenged aerosolized 14-16 studied day 18. Compared control Ag, displayed significantly reduced hyperresponsiveness, eosinophilia, Ag-specific IgG1 IgE, mucus metaplasia, cytokine secretion vivo restimulated vitro. results demonstrate that can prevent generation response development experimental These studies, those others, support notion lack ectoparasitism may contribute increasing prevalence