Complexity of human T-cell antigen receptor beta-chain constant- and variable-region genes.
作者： J. E. Sims , A. Tunnacliffe , W. J. Smith , T. H. Rabbitts
DOI: 10.1038/312541A0
关键词:
摘要: Immune systems of vertebrates function via two types effector cells, B and T which are capable antigen-specific recognition. The immunoglobulins, serve as antigen receptors on have been well characterized with respect to gene structure, unlike the T-cell receptors. Recently, cDNA clones thought correspond beta-chain locus human mouse receptor described. presumptive detect rearrangement specifically in DNA show homology immunoglobulin light chains. similarity system genes has further demonstrated by recent observation variable- constant-region segments joining putative diversity segments. We report here characterization genomic encoding genes. There (C beta 1 C 2), each expression RNA. arrangement, analogous that genes, shows strong evolutionary conservation dual these species.
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