Passive Immunization in JNPL3 Transgenic Mice Using an Array of Phospho-Tau Specific Antibodies
作者： Cristina d’Abramo , Christopher M. Acker , Heidy Jimenez , Peter Davies
DOI: 10.1371/JOURNAL.PONE.0135774
关键词:
摘要: Recent work from our lab and few others have strongly suggested that immunotherapy could be an effective means of preventing the development tau accumulation in JNPL3 transgenic mice, carrying human P301L mutation. The aim this study was to test efficacy a variety specific monoclonal antibodies JNPL3. Starting at 3 months age, mice were treated for 4 with weekly intraperitoneal injections saline or purified (10mg/Kg) different specificity pathological tau: CP13 (pSer202), RZ3 (pThr231) PG5 (pSer409). As expected, not all tested showed pathology described dose, some them even worsening scenario. Only by targeting pSer202 epitope conspicuous reduction insoluble soluble cortex hindbrain obtained. Here we report about importance screening vivo multiple order select direct into future clinical studies.
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