Calcium supplementation and the risk of preeclampsia in Ecuadorian pregnant teenagers.

摘要: Objective: To determine whether increased calcium intake (2 g/day) in pregnancy is effective reducing the risk of preeclampsia pregnant teenagers. Methods: The present study was a prospective, randomized, double-blind, controlled clinical trial. Two hundred sixty teenaged girls attending Hospital GinecoObstetrico Isidro Ayora Quito, Ecuador, were included. Selection criteria age less than 17.5 years, nulliparity, first prenatal visit before 20 weeks' gestation, and residency Quito (2800-m altitude). We used table random numbers to assign 125 receive 2000 mg elemental daily, beginning at weeks gestation continuing until delivery; 135 women control group received placebo. Blood pressure (BP) measured twice every 4 delivery 48 hours after delivery. diagnosis defined as BP greater 140/90 mmHg on least two occasions more 6 apart proteinuria 30 mg/dL (over one cross by dipstick 4–24 apart). Results: average daily this population approximately 51% Recommended Dietary Allowance. Calcium supplementation associated with significantly decreased (risk reduction 12.35%; P n = 4) developing treatment versus 15.5% ( 21) placebo group. Moreover, led systolic 9.1 diastolic 6.0 mmHg. Conclusion: These results suggest that during populations low safe, effective, inexpensive preventive measure reduces preeclampsia.