Concentration dependence of proteoglycan diffusion.

摘要: The mutual diffusion coefficient of the bovine nasal cartilage proteoglycan subunit is found to increase rapidly with increasing concentration and decreasing ionic strength. These results have been obtained by analysis boundary relaxation gradients in analytical ultracentrifuge schlieren optics. behavior can be understood terms nonideality proteoglycan. magnitude dominated charge interactions, whereas influence molecular size associated excluded-volume interactions small. dependence apparent from dynamic light scattering was found, contrast, decrease concentration. Computer simulation suggests that presence a small population aggregates may account for difference two types measurement due their marked on scattering.