ASPicDB: A Database Web Tool for Alternative Splicing Analysis

摘要: Alternative splicing (AS) is a basic molecular phenomenon that increases the functional complexity of higher eukaryotic transcriptomes. Indeed, through AS individual gene loci can generate multiple RNAs from same pre-mRNA. has been investigated in variety clinical and pathological studies, such as transcriptome regulation cancer. In human, recent works based on massive RNA sequencing indicate >95 % pre-mRNAs are processed to yield transcripts. Given biological relevance AS, several computational efforts have done leading implementation novel algorithms specific specialized databases. Here we describe web application ASPicDB allows recovery detailed information about mechanism. provides powerful querying systems interrogate events at gene, transcript, protein levels. Finally, includes visualization instruments browse export results for further off-line analyses.