Pediatric Methicillin-Resistant Staphylococcus aureus Osteoarticular Infections

摘要: Osteoarticular infections (OSI) are a significant cause of hospitalizations and morbidity in young children. The pediatric patient with OSI presents unique challenges diagnosis management due to higher morbidity, effect on growth plate associated long-lasting sequelae, early identification management. Methicillin-resistant Staphylococcus aureus (MRSA), first described the 1960s, has evolved rapidly emerge as predominant children, therefore empiric treatment for should include an antibiotic effective against MRSA. Characterizing MRSA strains can be done by antimicrobial susceptibility testing, detection Panton–Valentine leukocidin (PVL) gene, staphylococcal cassette chromosome mec (SCCmec) typing, pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST). Worldwide, community-onset methicillin-resistant disease is widespread mainly PVL-producing clone, ST8/USA300. Many studies have implied correlation between PVL genes more severe infection. We review along pertinent aspects its pathogenesis, clinical spectrum, diagnosis, current guidelines