Differential ventral septal vasopressin release is associated with sexual dimorphism in PGE2 fever.

摘要: The vasopressinergic innervation of the ventral septal area (VSA) has been shown to be implicated in antipyresis. Because this system is less well developed female rats, we hypothesized that rats would display exaggerated febrile responses. We therefore examined temperature responses conscious and urethan-anesthetized both sexes centrally administered prostaglandin E2 (PGE2) correlated these with release action endogenous arginine vasopressin (AVP) VSA. Both [25 ng/5 microliters PGE2 intracerebroventricularly (i.c.v.)] anesthetized (VSA microdialyzed, 50 i.c.v.) had higher fevers than did males. Infusion an AVP V1a receptor antagonist inverted question mark1 nmol [d(CH2)5Tyr(Me)]AVP mark plus gave rise males but not females. Measurements microdialysates VSA showed was increased response only. Baseline similar. results suggest there a sex-related difference fever, which may accounted for by differential