Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses.

摘要: Background: Maternal rectovaginal colonization with group B Streptococcus (GBS) is the most common pathway for GBS disease in mother, fetus, and newborn. This article, second a series estimating burden of GBS, aims to determine prevalence serotype distribution colonizing pregnant women worldwide. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American Caribbean Health Sciences Literature [LILACS], World Organization Library Information System [WHOLIS], Scopus), organized Chinese language searches, sought unpublished data from investigator groups. applied broad inclusion criteria maximize inputs, particularly low- middle-income contexts, then new meta-analyses adjust studies less-sensitive sampling laboratory techniques. undertook derive pooled estimates maternal at national regional levels. Results: The dataset regarding included 390 articles, 85 countries, total 299924 women. Our adjusted estimate worldwide was 18% (95% confidence interval [CI], 17%-19%), variation (11%-35%), lower Southern Asia (12.5% [95% CI, 10%-15%]) Eastern (11% 10%-12%]). Bacterial serotypes I-V account 98% identified isolates Serotype III, associated invasive disease, accounts 25% 23%-28%), but less frequent some South Asian countries. Serotypes VI-IX are more Asia. Conclusions: colonizes worldwide, vary, even after adjusting methods. Lower prevalence, may help explain incidence regions such as High data, relevant prevention efforts.