Beyond passive immunization: toward a nanoparticle-based IL-17 vaccine as first in class of future immune treatments

摘要: Nanoparticles occur naturally as part of repetitive molecular structures forming virus-like particles (VLPs). VLPs are powerful immune activators. Specifically, VLP can elicit a direct activation B lymphocytes to trigger production antibodies targeted at molecules chemically linked the VLP. We here review recent data from genetics research, large-scale genomic sequencing, well clinical trials which suggest that VLP-based vaccine against signaling molecule IL-17 will be safe and effective in common skin disease psoriasis, other conditions. Active vaccination is capable replacing costly manufacture currently use with huge implications for treatment availability health economics.