Pattern recognition by B cells: the role of antigen repetitiveness versus Toll-like receptors.
作者： H. J. Hinton , A. Jegerlehner , M. F. Bachmann
DOI: 10.1007/978-3-540-73900-5_1
关键词:
摘要: Viruses induce excellent antibody responses due to several intrinsic features. Their repetitive, organised structure is optimal for the activation of B cell receptor (BCR), leading an increased humoral response and a decreased dependence on T help. also trigger Toll-like receptors (TLRs), which in addition increasing overall Ig levels, drive switch IgG2a isotype. This isotype more efficient viral bacterial clearance will activate complement, turn lowers threshold BCR activation. Exploiting these characteristics vaccine design may help us create vaccines are as safe recombinant yet still effective virus inducing responses.
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B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms. Immunological Reviews. ,vol. 176, pp. 154- 170 ,(2000) , 10.1034/J.1600-065X.2000.00607.X
H D Ochs, S W Hosea, S R Heller, R J Wedgwood, M M Frank, The role of complement in the induction of antibody responses. Clinical and Experimental Immunology. ,vol. 53, pp. 208- 216 ,(1983)
Andrea Jegerlehner, Patrik Maurer, Juliana Bessa, Heather J. Hinton, Manfred Kopf, Martin F. Bachmann, TLR9 signaling in B cells determines class switch recombination to IgG2a. Journal of Immunology. ,vol. 178, pp. 2415- 2420 ,(2007) , 10.4049/JIMMUNOL.178.4.2415
K Kitajima, G G Klaus, M B Pepys, B A Askonas, Activation of mouse complement by different classes of mouse antibody. Immunology. ,vol. 38, pp. 687- 695 ,(1979)
M Hofnung, E Deriaud, C Leclerc, P Martineau, A Charbit, The cellular location of a foreign B cell epitope expressed by recombinant bacteria determines its T cell-independent or T cell-dependent characteristics. Journal of Immunology. ,vol. 147, pp. 3545- 3552 ,(1991)
K. E. Stein, J. J. Mond, B. Subbarao, W. E. Paul, Analysis of B Cell Activation Requirements with TNP-Conjugated Polyacrylamide Beads Journal of Immunology. ,vol. 123, pp. 239- 245 ,(1979)
W A Petri, R R Wagner, Reconstitution into liposomes of the glycoprotein of vesicular stomatitis virus by detergent dialysis. Journal of Biological Chemistry. ,vol. 254, pp. 4313- 4316 ,(1979) , 10.1016/S0021-9258(17)30004-2
T M Kündig, H Hengartner, B Odermatt, M F Bachmann, R M Zinkernagel, Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells. Journal of Immunology. ,vol. 153, pp. 3386- 3397 ,(1994)
Dominique Gatto, Christiane Ruedl, Bernhard Odermatt, Martin F. Bachmann, Rapid Response of Marginal Zone B Cells to Viral Particles Journal of Immunology. ,vol. 173, pp. 4308- 4316 ,(2004) , 10.4049/JIMMUNOL.173.7.4308
G Kelsoe, J Xia, S Han, R G Howard, M Ma, M C Carroll, M B Fischer, S Goerg, E Kremmer, T L Rothstein, O Finco, F S Rosen, X Zhou, Regulation of the B cell response to T-dependent antigens by classical pathway complement. Journal of Immunology. ,vol. 157, pp. 549- 556 ,(1996)