Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41.
作者： C. Pastori , D. Tudor , L. Diomede , A.S. Drillet , A. Jegerlehner
DOI: 10.1016/J.VIROL.2012.05.005
关键词:
摘要: Natural antibodies to gp41 inhibit HIV-1 replication through the recognition of two different regions, corresponding leucine zipper motif in HR1 alpha-helix and another within HR2 region, hosting 2F5 4E10 epitope. This study aimed at reproducing such protective responses VLP vaccination. Six regions covering alpha-helical were conjugated surface AP205 phage-based VLPs. Once administered mice via systemic or mucosal route, these immunogens elicited high titers gp41-specific IgG. Immunogenicity HIV infectivity reduction obtained either with peptides where aminoacid strings added C-terminus N-terminus core epitope region. Antibody-dependent cell cytotoxicity (ADCC) activity was induced by one epitopes only. These results may have relevant implications for development new vaccinal approaches against infection.
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