Conformationally specific viral immunogens
作者： Christopher Patrick Marshall
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摘要: The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, made using such methods, pharmaceutical compositions comprising complexes. Such may comprise one or more cross-links stabilize the conformation an antibody epitope, a quaternary neutralizing antibody, exhibit enhanced ability to elicit protective immune response when administered subject component vaccine.
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