Analysis of Matched Tumor and Normal Profiles Reveals Common Transcriptional and Epigenetic Signals Shared across Cancer Types

摘要: To identify the transcriptional regulatory changes that are most widespread in solid tumors, we performed a pan-cancer analysis using over 600 pairs of tumors and adjacent normal tissues profiled The Cancer Genome Atlas (TCGA). Frequency upregulation was calculated across mRNA expression levels, microRNA levels CpG methylation sites is provided here as resource. Frequent tumor-associated alterations were identified simple statistical approach. Many consistent with increased rate cell division cancer, such overexpression cycle genes hypermethylation PRC2 binding sites. However, also proliferation-independent alterations, which highlight novel pathways essential to tumor formation. Nearly all GABA receptors frequently downregulated, gene encoding delta subunit (GABRD) strongly upregulated notable exception. Metabolic particularly alcohol dehydrogenases others decreased role oxidative phosphorylation cancerous cells. Alterations composition metabolism may play key differentiation cancer cells, independent proliferation.