Importance of T-cell-dependent inflammatory reactions in the decline of microsomal cytochrome P450 concentration in the livers of rats infected with Fasciola hepatica.

摘要: The concentration of cytochrome P450, measured spectrophotometrically in microsomal preparations from the livers rats infected with 30 metacercariae Fasciola hepatica, declined by approximately 50% at 3 weeks post-infection. Treatment anti-inflammatory agent dexamethasone (2 mg/kg 48 h intervals for 8 days prior to assay) abolished decline P450 content. Assay congenitally athymic (nude) showed normal levels. These results demonstrate that T-cell-dependent inflammatory response liver host is a necessary factor development hepatic which known compromise metabolism certain drugs hosts.