摘要: Publisher Summary The congenitally athymic nude rat (rnu/rnu) is a genetic mutant found in Rattus norvegicus characterized by severe alteration the cell-mediated branch of immunity (CMI). Altered cellular immune responses are owing to lack appropriate development and education functional T-cell (thymus-derived) lymphocytes. size robustness absence major endocrinological abnormalities make it an experimental model for variety immunological, surgical, infectious, transplant-related, oncological procedures. Nude rats uniquely capable handling increased tumor burden without overt distress, additional body allows therapeutic intervention more easily than mouse. Therapeutic data anti-neoplastic studies presented terms (1) lifespan reflected relative median survival time treated verses control groups (%treated/control); (2) cures; or (3) times (in days) grow tumors predetermined target size. has demonstrated value many areas biomedical research. From basic function cells intricate interactions tumors, treatment, imaging modalities, provided robust suitable response.
sci-hub.se 参考文章(260)
S. Fossum, Differences Between Lymph Node Structure and Function in Normal and Athymic Rats Current Topics in Pathology. pp. 65- 83 ,(1990) , 10.1007/978-3-642-75519-4_3
John P. Mordes, Eugene S. Handler, Debra J. Waite, Dale L. Greiner, Aldo A. Rossini, Michael C. Appel, Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat American Journal of Pathology. ,vol. 148, pp. 2043- 2056 ,(1996)
X J Chen, L Enerbäck, IgE receptors, IgE content and secretory response of mast cells in athymic rats. Immunology. ,vol. 83, pp. 595- 600 ,(1994)
Rülicke T, Hassam S, Briner J, Autenried P, The elimination of mouse hepatitis virus by temporary transplantation of human tumors from infected athymic nude mice into athymic nude rats (rnuN/rnuN). Journal of Experimental Animal Science. ,vol. 34, pp. 127- ,(1991)
O. Sorensen, A. Saravani, S. Dales, In Vivo and In Vitro Models of Demyelinating Disease, XXIII: Infection by JHM Virus of Athymic Rats Coronaviruses. ,vol. 218, pp. 383- 390 ,(1987) , 10.1007/978-1-4684-1280-2_47
U Wiedermann, U Dahlgren, L A Hanson, L Enerbäck, X J Chen, T-cell-independent and T-cell-dependent IgE responses to the nematode Nippostrongylus brasiliensis: comparison of serum IgE and mast-cell-bound IgE. Immunology. ,vol. 86, pp. 351- 355 ,(1995)
R. O. Jacoby, E. A. Johnson, E. C. Weir, F. X. Paturzo, R. B. Ardito, Persistence of sialodacryoadenitis virus in athymic rats. Laboratory Animal Science. ,vol. 40, pp. 138- 143 ,(1990)
A. D. Moscioni, P. Lahiri, N. R. Chowdhury, A. A. Demetriou, Z. Khan, D. Shouval, P. R. Yerneni, J. R. Chowdhury, Bilirubin conjugates produced by human, dog, and rat hepatocytes transplanted into athymic Gunn rats. Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians. ,vol. 2, pp. 58- 63 ,(1991)
Bengt Glimelius, Wilhelm Graf, Håkan Ahlström, Anders Magnusson, Anders Sundín, Contrast-enhanced CT scanning in vivo for the quantification of hepatic metastases from a human colonic cancer in the nude rat. Ejso. ,vol. 18, pp. 615- 623 ,(1992)
E. Balish, Experimental mycoses in congenitally immunodeficient rodents. Archives of Medical Research. ,vol. 24, pp. 225- 231 ,(1993)