Bisthiazole inhibitors of pro-matrix metalloproteinase activation
作者： Brett Andrew Tounge , Umar S.M. Maharoof , Michael Hawkins , Joseph Kent Barbay , Paul Francis Jackson
DOI:
关键词:
摘要: This invention relates to thiazole I and its therapeutic prophylactic uses, wherein the variables R z , Q, J, 1 3 5 6 are defined in specification. Disorders treated and/or prevented include rheumatoid arthritis.
lens.org参考文章(12)
Steven M. Rubenstein, Jonathan B. Houze, Lawrence R. Mcgee, Hisashi Shinkai, Noboru Furukawa, Atsushi Hagiwara, Quinolinyl and benzothiazolyl ppar-gamma modulators ,(2001)
Ralph Mazitschek, Frank Stieber, Athanassios Giannis, Herbert Waldmann, Klaus Hellmuth, 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2 ,(2003)
Nele Vandermaesen, Marc J. De Brabander, Roger Clive Moses, Christopher John Love, Anthony William Sibley, Caterina Noula, Gaston Stanislas Marcella Diels, Jean Pierre Frans Van Wauwe, Ludwig Paul Cooymans, Mykhalyo Goncharenko, 2,4,5-trisubstituted thiazolyl derivatives and their antiinflammatory activity ,(2002)
Daniel Timothy Kohlman, Frantz Victor, Bai-Ping Ying, Michael Philip Cohen, Yao-Chang Xu, Deyi Zhang, Sidney Xi Liang, DeAnna Piatt Zacherl, Pyridinoylpiperidines as 5-HT1F agonists ,(2003)
Vincent Pomel, Jérôme Dorbais, David Covini, Anna Quattropani, Thomas Rueckle, Thiazole derivatives and use thereof ,(2006)
Eli Breuer, Julia Frant, Reuven Reich, Recent non-hydroxamate matrix metalloproteinase inhibitors Expert Opinion on Therapeutic Patents. ,vol. 15, pp. 253- 269 ,(2005) , 10.1517/13543776.15.3.253
Kenneth J. Wilson, Carl R. Illig, Nalin Subasinghe, James B. Hoffman, M. Jonathan Rudolph, Richard Soll, Christopher J. Molloy, Roger Bone, David Green, Troy Randall, Marie Zhang, Frank A. Lewandowski, Zhao Zhou, Celia Sharp, Diane Maguire, Bruce Grasberger, Renee L. DesJarlais, John Spurlino, Synthesis of thiophene-2-carboxamidines containing 2-amino-thiazoles and their biological evaluation as urokinase inhibitors Bioorganic & Medicinal Chemistry Letters. ,vol. 11, pp. 915- 918 ,(2001) , 10.1016/S0960-894X(01)00102-0
Siavosh Mahboobi, Andreas Sellmer, Heymo Höcher, Emerich Eichhorn, Thomas Bär, Mathias Schmidt, Thomas Maier, Josef F. Stadlwieser, Thomas L. Beckers, [4-(Imidazol-1-yl)thiazol-2-yl]phenylamines. A Novel Class of Highly Potent Colchicine Site Binding Tubulin Inhibitors: Synthesis and Cytotoxic Activity on Selected Human Cancer Cell Lines Journal of Medicinal Chemistry. ,vol. 49, pp. 5769- 5776 ,(2006) , 10.1021/JM060545P
Gui Jun Yu, Choong L. Yoo, Baoxue Yang, Michael W. Lodewyk, Liping Meng, Tamer T. El-Idreesy, James C. Fettinger, Dean J. Tantillo, A. S. Verkman, Mark J. Kurth, Potent s-cis-locked bithiazole correctors of ΔF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy Journal of Medicinal Chemistry. ,vol. 51, pp. 6044- 6054 ,(2008) , 10.1021/JM800533C
Subramaniam Ananthan, Ellen R. Faaleolea, Robert C. Goldman, Judith V. Hobrath, Cecil D. Kwong, Barbara E. Laughon, Joseph A. Maddry, Alka Mehta, Lynn Rasmussen, Robert C. Reynolds, John A. Secrist, Nice Shindo, Dustin N. Showe, Melinda I. Sosa, William J. Suling, E. Lucile White, High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis. ,vol. 89, pp. 334- 353 ,(2009) , 10.1016/J.TUBE.2009.05.008