Nanostructured chitosan/gelatin/bioactive glass in situ forming hydrogel composites as a potential injectable matrix for bone tissue engineering
作者： Cheisy D.F. Moreira , Sandhra M. Carvalho , Ricardo G. Sousa , Herman S. Mansur , Marivalda M. Pereira
DOI: 10.1016/J.MATCHEMPHYS.2018.07.039
关键词:
摘要: Tissue engineering using soft materials has become a very promising approach for repairing damaged cartilage and bone tissue. In this study, novel in situ forming composite hydrogels were synthesized based on chitosan and gelatin biopolymers associated with bioactive glass nanoparticles. The zeta potential at 37° C ranged from+ 3.1±1.4 mV to+ 6.9±3.2 mV and showed the cationic nature of these hydrogels, which are capable of interacting with negatively charged molecules from native extracellular matrix (ECM). Moreover, the zeta …
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