The effect of caffeic acid phenethyl ester on the prevention of experimentally induced myringosclerosis.
作者： Jae-Jun Song , Seong Keun Kwon , Chang Gun Cho , Seok-Won Park
DOI: 10.1016/J.IJPORL.2007.05.003
关键词:
摘要: Summary Objectives Myringosclerosis is a common sequela of ventilation tube insertion for the treatment otitis media with effusion. Several antioxidants have been identified to prevent myringosclerosis. The objective this study was investigate effect caffeic acid phenethyl ester (CAPE) on prevention experimentally induced Methods Thirty-five Sprague–Dawley rats were unilaterally myringotomized. divided into four groups randomly: group 1 received no treatment, 2 intraperitoneally administered saline and 3 CAPE. tympanic membranes examined by otomicroscopy 15th day after treatment. then harvested evaluated histologically light microscopy. Results from showed extensive myringosclerosis; those similar occurrence However, had reduced myringosclerosis otomicroscopic evaluation. Under microscopic examination, lamina propria pars tensa found be thicker more sclerotic in when compared 3. Conclusions Systemic CAPE effective lesions myringotomized rat membranes.
elsevier.com
sci-hub.se 参考文章(17)
Hui-Fen Liao, Yu-Ywan Chen, Jun-Jen Liu, Ming-Ling Hsu, Hui-Ju Shieh, Hung-Jen Liao, Chwen-Jen Shieh, Ming-Shi Shiao, Yu-Jen Chen, Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis. Journal of Agricultural and Food Chemistry. ,vol. 51, pp. 7907- 7912 ,(2003) , 10.1021/JF034729D
Cecilia Mattsson, Cathrine Johansson, Sten Hellström, Myringosclerosis Develops within 9 h of Myringotomy Operations Research Letters. ,vol. 61, pp. 31- 36 ,(1999) , 10.1159/000027635
C. Mattsson, S. Hellström, Inhibition of the development of myringosclerosis by local administration of fenspiride, an anti-inflammatory drug European Archives of Oto-rhino-laryngology. ,vol. 254, pp. 425- 429 ,(1997) , 10.1007/BF02439973
Jorge E. Spratley, Sten O. Hellström, Cecilia K. Mattsson, Manuel Pais-Clemente, Topical Ascorbic Acid Reduces Myringosclerosis in Perforated Tympanic Membranes a Study in the Rat Annals of Otology, Rhinology, and Laryngology. ,vol. 110, pp. 585- 591 ,(2001) , 10.1177/000348940111000615
Chong‐Kuei Lii, Yuh‐Jane Ko, Ming‐Tsai Chiang, Wei‐Che Sung, Haw‐Wen Chen, Effect of dietary vitamin E on antioxidant status and antioxidant enzyme activities in Sprague-Dawley rats Nutrition and Cancer. ,vol. 32, pp. 95- 100 ,(1998) , 10.1080/01635589809514725
Kyung-Min Shin, In-Tae Kim, Young-Mi Park, Joohun Ha, Jong-Won Choi, Hee-Juhn Park, Yong Sup Lee, Kyung-Tae Lee, Anti-inflammatory effect of caffeic acid methyl ester and its mode of action through the inhibition of prostaglandin E2, nitric oxide and tumor necrosis factor-α production Biochemical Pharmacology. ,vol. 68, pp. 2327- 2336 ,(2004) , 10.1016/J.BCP.2004.08.002
Cengiz Özcan, Kemal Görür, Leyla Cinel, Derya Ümit Talas, Murat Ünal, İsmail Cinel, The inhibitory effect of topical N-acetylcysteine application on myringosclerosis in perforated rat tympanic membrane International Journal of Pediatric Otorhinolaryngology. ,vol. 63, pp. 179- 184 ,(2002) , 10.1016/S0165-5876(01)00640-1
K. Natarajan, S. Singh, T. R. Burke, D. Grunberger, B. B. Aggarwal, Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 9090- 9095 ,(1996) , 10.1073/PNAS.93.17.9090
Kemal Görür, Cengiz Özcan, Ayse Polat, Murat Ünal, Lülüfer Tamer, İsmail Cinel, The anti-oxidant and anti-apoptotic activities of selenium in the prevention of myringosclerosis in rats. Journal of Laryngology and Otology. ,vol. 116, pp. 426- 429 ,(2002) , 10.1258/0022215021911202
Cecilia Mattsson, Lena Carlsson, Stefan L. Marklund, Sten Hellström, Myringotomized Mice Develop Myringosclerosis in the Pars Flaccida and Not in the Pars Tensa The Laryngoscope. ,vol. 107, pp. 200- 205 ,(1997) , 10.1097/00005537-199702000-00011