Cytomegalovirus infection in burns: a review

摘要: Sepsis is responsible for significant morbidity and mortality in patients suffering from severe burn injuries. Burn are known to be immunocompromised, it generally accepted that the immunosuppressed patient may experience human cytomegalovirus (HCMV) infection disease. Review of very limited available literature identifies a seroconversion rate between 18 22 % who were seronegative HCMV prior their injury. Furthermore, approximately 50 antibody-positive reactivate. Blood products allografted skin have clinically been identified as possible sources transmission patients. Experience treatment or disease scarce immunoglobulin therapy. Animal experiments demonstrated murine (MCMV)-seropositive grafts able infect immunodeficient mice well burned mice. Murine studies also with MCMV enhances susceptibility secondary bacterial increases these animals. Burned challenged significantly higher level translocation mesenteric lymph nodes than either control thermally injured without inoculation non-burned injected alone. In summary, remains controversial whether per se alters outcome majority Subgroups severely burned, benefit blood donors. Antiviral strategies not yet evaluated patient. Further investigations utilizing modern diagnostic techniques seem necessary.