Gene Expression Profiling Reveals Two Distinct Subtypes of Merkel Cell Carcinoma

摘要: Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine tumor of the skin. The genetic mechanisms underlying development and progression MCC are poorly understood. We showed by comparative genomic hybridization analysis that pattern chromosomal abnormalities in resembles small lung (SCLC). Both tumors also share clinical immunophenotypical characteristics. In addition, lines can be grouped, analogous to SCLC, into two different biological subgroups, namely Variant versus Classic lines. order obtain more insight molecular pathogenesis find typical gene expression signatures associated with phenotypically subgroups lines, we determined profiles five use Atlas cDNA arrays. Supervised allowed us identify set 89 highly significant differentially expressed genes, which classification subgroups. Genes mainly involved cycle proliferation higher levels reflecting their behavior. signal transduction, neurotransmission neuronal level types differentiated character. assume differential some these genes refleet, properties phenotypes. Some could serve as useful prognostic markers potential targets for new therapeutic interventions specific each subgroup.