Echocardiographic assessment of the impact of exercise training at different time points of the development of experimental pulmonary arterail hypertension

摘要: Background: Pulmonary hypertension triggers right ventricle remodeling that inexorably leads to its failure. Although it selectively overloads the ventricle, left ventricular dysfunction also manifests in course of primary PH. We investigated whether exercise training at different time points could act as a modulator, preventing bi-ventricular monocrotaline (MCT) model PAH. Methods: Male Wistar rats were randomly divided into four groups and submitted echocardiographic protocol: SED+CONT, SED+MCT (n=5; normal cage activity injected with saline or (MCT, 60 mg / kg), n=7, respectively) treadmill chronic during (EXafter+MCT, n=6) after (EXtreat+MCT, n=7) establishment RV pressure overload. Results: Exercise averted significant systolic function (TAPSE, S’ AIV, P<0.05 vs. SED+MCT) diastolic (IVRT, atrium, end-diastolic Tau, improvement all MCT-trained groups. This effects lead increase cardiac output (SED+CONT 4.7±0.8 L/min, EXafter+MCT 3.6±0.6 EXtreat+MCT 2.1±0.5 L/min 1.7±0.2 L/min) exercice tolerance MCTtrained Conclusions: These data demonstrate beneficial an experimental PAH, emphasizing potential possible adjunctive treatment option.