Exercise training in patients with chronic heart failure delays ventilatory anaerobic threshold and improves submaximal exercise performance.

摘要: We have recently demonstrated that exercise training can induce important hemodynamic and metabolic adaptations in patients with chronic heart failure due to severe left ventricular dysfunction. This study examines the accompanying changes submaximal performance ventilatory response these patients. Before after 16-24 weeks of training, subjects underwent two symptom-limited bicycle tests, one an incremental graded workload, a constant workload represented 79 +/- 11% pretraining peak oxygen consumption. Breath-by-breath expired gas analysis was performed continuously during each test, central hemodynamic, leg blood flow, lactate measurements were obtained protocol. The anaerobic threshold determined from coplotted breath-by-breath data standard criteria by observers who unaware patient identity or status. As previously reported, increased consumption 23% 16.8 3.8 20.6 4.7 ml/kg/min reduced levels exercise. training-induced decrease accumulation accompanied carbon dioxide production, respiratory exchange ratio, ventilation delayed 284 43 352 91 seconds (p = 0.02), it occurred at (10.1 1.2 vs. 12.1 2.6 ml/kg/min, p 0.01). Exercise duration protocol 938 410 1,429 691 less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)