Development of a buccal doxepin platform for pain in oral mucositis derived from head and neck cancer treatment.

摘要: This study describes the development of semisolid formulations containing doxepin (DOX) for pain relief in oral mucositis, frequently related to chemotherapy and/or radiotherapy treatments patients with head and neck cancer. Chemical permeation enhancers were evaluated selected according results obtained from rheological studies, drug release, retention through buccal mucosa. Finally, formulation was compared vivo, a reference DOX mouthwash, whose clinical efficacy had been previously reported. The findings showed that an orabase® platform loading transcutol® (10%) menthol (5%) vehiculization exhibited decreased elastic viscous behavior improving its application. main release mechanism could be considered as diffusion Higuchi model. Obtained rates optimal analgesic effect far below antidepressant activity. Similar vivo plasma concentrations found mouthwash. However, amounts retained mucosa animals higher than reference, which let us hypostatize even stronger potential local therapeutic additional advantages such as, mucoadhesive properties, absence alcohol, some degree freshness, well palatability improvement.