Specific treatment of hepatosplenic schistosomiasis can increase T-lymphocyte reactivity
作者： Maria Imaculada Muniz-Junqueira , José Tavares-Neto , Meire Ataide , Aluizio Prata , Carlos Eduardo Tosta
DOI: 10.1590/S0037-86821991000200005
关键词:
摘要: It has been recognized that Schistosoma mansoni infection causes depression of T-cell responsiveness. In this study we have evaluated whether immunodepression associated to schistosomiasis could be reverted by specific treatment. immune response was assessed means intradermal tests using recall antigens in a group 22 patients with hepatosplenic schistosomiasis, one year after treatment oxamniquine and compared untreated patients. Only 27% treated presented complete anergy all tested antigens, marked contrast 80% unresponsiveness showed without Although most the individuals some still persisted Anergy not found any normal individual control group. concluded infected may recover their responsiveness elimination worm
sci-hub.se 参考文章(19)
F Gutteridge, Human experimentation and medical ethics. International guidelines for biomedical research involving human subjects. Who Chronicle. ,vol. 35, pp. 212- 215 ,(1981)
J. A. Grimaud, Z. A. Andrade, Evolution of the schistosomal hepatic lesions in mice after curative chemotherapy. American Journal of Pathology. ,vol. 124, pp. 59- 65 ,(1986)
Mitsuyoshi KUMADA, Yukio HOSAKA, Masato KAWABATA, Hiroko ASAHI, Keiko KATO, Takatoshi KOBAYAKAWA, Shigeo HAYASHI, RECOVERY FROM IMMUNESUPPRESSION IN MICE INFECTED WITH SCHISTOSOMA JAPONICUM BY TREATMENT OF PRAZIQUANTEL Japanese journal of medical science & biology. ,vol. 40, pp. 89- 93 ,(1987) , 10.7883/YOKEN1952.40.89
F.S. Rosen, R.J. Wedgwood, M. Eibl, F. Aiuti, M.D. Cooper, R.A. Good, C. Griscelli, L.A. Hanson, W.H. Hitzig, S. Matsumoto, M. Seligmann, J.F. Soothill, T.A. Waldmann, Primary immunodeficiency diseases: Report of a World Health Organization Scientific Group Clinical Immunology and Immunopathology. ,vol. 40, pp. 166- 196 ,(1986) , 10.1016/0090-1229(86)90082-6
Richard W. Goodgame, Fred A. Lewis, Charles W. Todd, Daniel G. Colley, Immune Responses During Human Schistosomiasis Mansoni VI. In Vitro Nonspecific Suppression of Phytohemagglutinin Responsiveness Induced by Exposure to Certain Schistosomal Preparations Journal of Immunology. ,vol. 122, pp. 1447- 1453 ,(1979)
Chaves A, Katz N, Pellegrino J, A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni. Revista Do Instituto De Medicina Tropical De Sao Paulo. ,vol. 14, pp. 397- 400 ,(1972)
R. P. Pelley, D. L. Boros, K. S. Warren, Spontaneous Modulation of Granulomatous Hypersensitivity in Schistosomiasis Mansoni Journal of Immunology. ,vol. 114, pp. 1437- 1441 ,(1975)
Zilton A. Andrade, Kenneth S. Warren, Mild prolonged schistosomiasis in mice: alterations in host response with time and the development of portal fibrosis. Transactions of The Royal Society of Tropical Medicine and Hygiene. ,vol. 58, pp. 53- 57 ,(1964) , 10.1016/0035-9203(64)90068-9
J. C. Bina, Aluizio Prata, Regressão da hepatosplenomegalia pelo tratamento específico da esquistossomose Revista Da Sociedade Brasileira De Medicina Tropical. ,vol. 16, pp. 213- 218 ,(1983) , 10.1590/S0037-86821983000400008
B.J. Cottrell, D. Humber, R.F. Sturrock, H. Seitz, P. Rees, Non-specific cell mediated immunity in patients infected with Schistosoma mansoni in Kenya Transactions of the Royal Society of Tropical Medicine and Hygiene. ,vol. 76, pp. 234- 237 ,(1982) , 10.1016/0035-9203(82)90285-1