Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes

摘要: Lung cancer is emerging as a paradigm for disease molecular subtyping, facilitating targeted therapy based on driving somatic alterations. Here we perform transcriptome analysis of 153 samples representing lung adenocarcinomas, squamous cell carcinomas, large cancer, adenoid cystic carcinomas and lines. By integrating our data with The Cancer Genome Atlas published sources, analyse 753 gene fusions other transcriptomic We show that higher numbers an independent prognostic factor poor survival in cancer. Our confirms the recently reported CD74-NRG1 fusion suggests NRG1, NF1 Hippo pathway may play important roles tumours without known driver mutations. In addition, observe exon-skipping events c-MET, which are attributable to splice site These classes genetic aberrations significant role genesis cancers lacking