Bcl-2/Bax Expression Levels Tend to Influence AMPAergic Trafficking Mechanisms During Hibernation in Mesocricetus auratus

摘要: Hypothermia is a physiological condition assuring brain protection against hypoxic-related damages. In this con- text, investigations carried out on the facultative hibernator Mesocricetusauratusprovedtobeveryusefulfor establishing thetypeofneurosignalingroleexertedbycerebral α-amino-3- hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) subtypes during hypoxic/reperfusion injuries of entrance (EN), torpor (TORP), and arousal (AROU) hi- bernating states. From evaluation major AMPARs (GluR1 GluR2), together with their scaffold proteins synapse-associated protein 97 kDa (SAP97) PICK1, it resulted that GluR1 SAP97 were mostly upregulated hypotensive (EN TORP) states brainstem, amygdala, hypothalamus, sites which are im- plicated cardiovascular, motor, sleep-wake events. addition, elevated expression densities pro-apoptotic factor Bcl-2-associated X (Bax) to be corre- lated marked amino-cupric-silver stain signals both hibernating Conversely, an increase neuroprotec- tive GluR2, PICK1 anti-apoptotic B cell lymphoma 2 (Bcl-2), appeared linked re- duced argyrophilic in most above areas hypertensive AROU state. These first indications highlight distinct protective/degenerative measures factors constituting key on/off switches various hibernat- ing may provide potential therapeutic bearings sleeping disorders.