2-amido-2-[2-(4-alkylphenyl)ethyl]-1,3-methyl glycol preparation method

摘要: The invention provides a preparation method for (I) 2- amido -2-[2-(4- alkyl phenyl)ethyl]-1u¼3- propanediol, which comprises: using benzene (II) as initial material, with Lewis acid existing, to take Friedel-Crafts acylating reaction 3- halogenated propionyl chloride and generate beta- alkylpropiophenone (IV); reducing IV by hydride obtain nitro -1-(4- phenyl) propanol (V); preparing -2- methylol -4-(4- phenyl)-1u¼4butanediol (VI) hydroxymethylation; removing benzalcoholhydroxy VI obtaining the objective product.