Chemotherapeutic strategies for treatment of colorectal cancer: present and future developments.

摘要: Colorectal cancer is one of the most common malignancies in Western nations. Treatment with 5-fluorouracil and leucovorin resulting inhibition DNA synthesis after thymidylate synthase strategy for adjuvant systemic chemotherapy this disease. However, majority patients still fail to respond combination; therefore, new chemotherapeutic strategies have been developed. This process has proceeded rapidly due a more proper translation preclinical results clinic. Knowledge proximal parameters (drug activation, drug-target interaction) distal (cell growth inhibitory cell death parameters) drug response should offer opportunity discriminate between sensitivity resistance therapeutic selectivity. clinical commentary presents review symposium held at Vrije Universiteit Medical Center, Amsterdam, The Netherlands, which focused on both aspects relating treatment colorectal cancer.