Protective effect of Co-enzyme Q10 On doxorubicin-induced cardiomyopathy of rat hearts
作者： Pei-Yu Chen , Chien-Wen Hou , Marthandam Asokan Shibu , Cecilia Hsuan Day , Peiying Pai
DOI: 10.1002/TOX.22270
关键词:
摘要: Q10 is a powerful antioxidant often used in medical nutritional supplements for cancer treatment. This study determined whether could effectively prevent cardio-toxicity caused by doxorubicin Four week old SD rats were segregated into groups namely control, group (challenged with doxorubicin), Dox + Q10 (with challenge and oral treatment), treatment). Doxorubicin received IP (2.5 mg/kg) every 3 days (10 day. Three weeks of significant reduction heart weight, disarray cardiomyocyte arrangement, elevation collagen accumulation, enhancement fibrosis cell death associated proteins, inhibition survival proteins. However, protected cardiomyocytes ameliorated induced doxorubicin. is, therefore, evidently potential drug to damage © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 679-689, 2017.
utsystem.edu参考文章(60)
Sandra M. Swain, Fredrick S. Whaley, Michael S. Ewer, Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer. ,vol. 97, pp. 2869- 2879 ,(2003) , 10.1002/CNCR.11407
Raymond B. Weiss, The anthracyclines: will we ever find a better doxorubicin? Seminars in Oncology. ,vol. 19, pp. 670- 686 ,(1992) , 10.5555/URI:PII:009377549290036Z
Sarah L. Molyneux, Christopher M. Florkowski, Peter M. George, Anna P. Pilbrow, Christopher M. Frampton, Michael Lever, A. Mark Richards, Coenzyme Q10 Journal of the American College of Cardiology. ,vol. 52, pp. 1435- 1441 ,(2008) , 10.1016/J.JACC.2008.07.044
Y. Shi, M. Moon, S. Dawood, B. McManus, P.P. Liu, Mechanisms and management of doxorubicin cardiotoxicity Herz. ,vol. 36, pp. 296- 305 ,(2011) , 10.1007/S00059-011-3470-3
Hsien-Tsung Yao, Yu-Chi Yang, Chen-Hui Chang, Hui-Ting Yang, Mei-Chin Yin, Protective effects of (-)-epigallocatechin-3-gallate against acetaminophen-induced liver injury in rats) IEEE Transactions on Biomedical Engineering. ,vol. 5, pp. 15- 15 ,(2015) , 10.7603/S40681-015-0015-8
Cheng-Yen Tsai, Su-Ying Wen, Marthandam Asokan Shibu, Yao-Chih Yang, Hanjing Peng, Binghe Wang, Yu-Min Wei, Hung-Yu Chang, Cheng-Yu Lee, Chih-Yang Huang, Wei-Wen Kuo, Diallyl trisulfide protects against high glucose–induced cardiac apoptosis by stimulating the production of Cystathionine gamma-lyase-derived hydrogen sulfide International Journal of Cardiology. ,vol. 195, pp. 300- 310 ,(2015) , 10.1016/J.IJCARD.2015.05.111
Hung-En Liao, Marthandam Asokan Shibu, Wei-Wen Kuo, Pei-Ying Pai, Tsung-Jung Ho, Chia-Hua Kuo, Jing-Ying Lin, Su-Ying Wen, Vijaya Padma Viswanadha, Chih-Yang Huang, Deep sea minerals prolong life span of streptozotocin-induced diabetic rats by compensatory augmentation of the IGF-I-survival signaling and inhibition of apoptosis. Environmental Toxicology. ,vol. 31, pp. 769- 781 ,(2016) , 10.1002/TOX.22086
Chao-Hung Lai, Chien-Kuo Han, Marthandam Asokan Shibu, Pei Ying Pai, Tsung-Jung Ho, Cecilia Hsuan Day, Fuu-Jen Tsai, Chang-Hai Tsai, Chun-Hsu Yao, Chih-Yang Huang, Lumbrokinase from earthworm extract ameliorates second-hand smoke-induced cardiac fibrosis Environmental Toxicology. ,vol. 30, pp. 1216- 1225 ,(2015) , 10.1002/TOX.21993
Ibtissem Ben Amara, Nejla Soudani, Ahmed Hakim, Afef Troudi, Khaled Mounir Zeghal, Tahia Boudawara, Najiba Zeghal, Protective effects of vitamin E and selenium against dimethoate-induced cardiotoxicity in vivo: biochemical and histological studies. Environmental Toxicology. ,vol. 28, pp. 630- 643 ,(2013) , 10.1002/TOX.20759
Catherine K. Yeung, Frederic T. Billings, Adam J. Claessens, Baback Roshanravan, Lori Linke, Mary B. Sundell, Suhail Ahmad, Baohai Shao, Danny D. Shen, T. Alp Ikizler, Jonathan Himmelfarb, Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress BMC Nephrology. ,vol. 16, pp. 183- 183 ,(2015) , 10.1186/S12882-015-0178-2