Protective effects of (-)-epigallocatechin-3-gallate against acetaminophen-induced liver injury in rats)
作者： Hsien-Tsung Yao , Yu-Chi Yang , Chen-Hui Chang , Hui-Ting Yang , Mei-Chin Yin
DOI: 10.7603/S40681-015-0015-8
关键词: CYP3A 、 Toxicity 、 Metabolism 、 Acetaminophen 、 Cytochrome P450 、 Liver injury 、 CYP2E1 、 Pharmacology 、 Catechin 、 Medicine
摘要: (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant catechin with various biological activities found in tea. In this study, effects of EGCG on metabolism and toxicity acetaminophen rat liver were investigated. Male Sprague-Dawley rats fed a controlled diet without or (0.54 %, w/w) for 1 week then intraperitoneally injected (1 g/kg body weight) killed after 12 h. Concentrations its conjugates plasma determined. The cytochrome P450 (CYP) phase II enzymes also evaluated. Rats had lower alanine aminotransferase aspartate activities, as indices hepatotoxicity, treatment. Morphological damage by was diet. addition, significantly reduced hepatic midazolam 1-hydroxylation (CYP3A), nitrophenol 6-hydroxylase (CYP2E1), UDP-glucurosyltransferase, sulfotransferase. Finally, feeding acetaminophen-glucuronate acetaminophen-glutathione contents liver. These results indicate that may reduce rats.
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