Evaluating the profile of selected cytokines in patients with food allergy and chronic gastritis.

摘要: INTRODUCTION Evaluating the profile of selected cytokines in patients with food allergy and chronic gastritis. Cytokines are produced by many cells they play a role mediators development local systemic inflammatory reaction. The aim study was to determine serum concentrations IL-4, IL-5, IL-8, TNF alpha gastritis allergy, who had been infected H. pylori. MATERIAL AND METHODS conducted on atopic diathesis, were allergic certain foods. group consisted 71 patients, including 42 females aged 16-54 years (mean age 35.5 years) 29 males 18-60 36.2 years). One control formed 40 non-atopic 18-56 34.8 years), suffering from other 30 subjects diagnosis functional dyspepsia. Serum levels determined kits manufactured ENDOGEN (Cambridge MA, USA) using enzyme immunoassay ELISA. parameters two tests given as mean value. RESULTS Mean Il-4 level 27.85 pg/ml, while it 13.26 pg/ml 4.3 concentration IL-5 ranged between 0 111.3 value: 7.43 pg/ml) allergy. Comparative analysis IL-4 showed presence statistically significant differences (p < 0.001). remaining cytokines, i.e. IL-8 increase when compared dyspepsia, without changes. CONCLUSIONS Chronic exposure allergen makes rise. In pylori infection, suggests that both infectious factors an important pathogenesis inflammation.