Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion

作者: Baoge Qu , Jiliang Su , Zhongdong Wang , Yafei Wang , Xinghai Han

DOI: 10.1371/JOURNAL.PONE.0129352

关键词: PhysiologyCagAIngestionHelicobacter pyloriImmunologyOxidative stressGroup AGroup BMalondialdehydeBiologyAlcohol

摘要: Different amounts of ingested alcohol can have distinct effects on the human body. However, there is limited research chronic consumption with Helicobacter pylori infection. We sought to investigate relationship between cytokine profile, oxidative balance and H. infection in subjects consumption. A total 142 were divided into three groups: 59 ingestion (group A); 53 without B); 30 control C). The serum levels CagA, interleukin (IL)-10, E-selectin, TNF-α, malondialdehyde (MDA) superoxide dismutase (SOD) activity measured by enzyme-linked immunosorbent assay (ELISA). found that ages CagA among groups, as well both mean drinking age daily groups B, matched comparable. Comparing BMIs BMI differences be statistically significant (F=3.921, P 0.05). Additionally, no comparisons (all P>0.05). IL-10 E-selectin group significantly lower than those B (serum IL-10: Furthermore, higher C Although MDA SOD slightly C, In conclusion, we believe might cause a inhibition certain profiles ingestion. Moreover, chronically may exert an adjusted inflammatory effect, but was association infection, balance.

参考文章(42)
Yasuaki Saijo, H pylori seropositivity and cytokine gene polymorphisms World Journal of Gastroenterology. ,vol. 13, pp. 4445- 4451 ,(2007) , 10.3748/WJG.V13.I33.4445
Zbikowska-Gotz M, Bartuzi Z, Sinkiewicz W, Romański B, Evaluating the profile of selected cytokines in patients with food allergy and chronic gastritis. Medical Science Monitor. ,vol. 6, pp. 1128- ,(2000)
Nawfal R. Hussein, Richard H. Argent, Christian K. Marx, Sapna R. Patel, Karen Robinson, John C. Atherton, Helicobacter pylori dupA Is Polymorphic, and Its Active Form Induces Proinflammatory Cytokine Secretion by Mononuclear Cells The Journal of Infectious Diseases. ,vol. 202, pp. 261- 269 ,(2010) , 10.1086/653587
Sergio A Con, Hiroaki Takeuchi, Gil R Con-Chin, Vicky G Con-Chin, Nobufumi Yasuda, Reinaldo Con-Wong, Role of bacterial and genetic factors in gastric cancer in Costa Rica. World Journal of Gastroenterology. ,vol. 15, pp. 211- 218 ,(2009) , 10.3748/WJG.15.211
Jung Mook Kang, Nayoung Kim, Dong Ho Lee, Ji Hyun Park, Mi Kyoung Lee, Joo Sung Kim, Hyun Chae Jung, In Sung Song, The Effects of Genetic Polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced Gastroduodenal Diseases in Korea Journal of Clinical Gastroenterology. ,vol. 43, pp. 420- 428 ,(2009) , 10.1097/MCG.0B013E318178D1D3
Santosh K. Tiwari, G. Manoj, Vishwas Sharma, G. Sivaram, R. Saikant, Avinash Bardia, Varun K. Sharma, Zakia Abid, Aleem A. Khan, M. Aejaz Habeeb, C. M. Habibullah, B. Santhosh Kumar, Amrita Nandan, Relevance of Helicobacter pylori genotypes in gastric pathology and its association with plasma malondialdehyde and nitric oxide levels Inflammopharmacology. ,vol. 18, pp. 59- 64 ,(2010) , 10.1007/S10787-010-0031-Y
Fei Wang, Wenbo Meng, Bingyuan Wang, Liang Qiao, Helicobacter pylori-induced gastric inflammation and gastric cancer Cancer Letters. ,vol. 345, pp. 196- 202 ,(2014) , 10.1016/J.CANLET.2013.08.016
Zhi-Gang Huang, Guang-Cai Duan, Qing-Tang Fan, Wei-Dong Zhang, Chun-Hua Song, Xue-Yong Huang, Rong-Guang Zhang, Mutation of cytotoxin-associated gene A affects expressions of antioxidant proteins of Helicobacter pylori World Journal of Gastroenterology. ,vol. 15, pp. 599- 606 ,(2009) , 10.3748/WJG.15.599
Michinaga Matsumoto, Hirokazu Yokoyama, Haruko Shiraishi, Hidekazu Suzuki, Shinzo Kato, Souichiro Miura, Hiromasa Ishii, Alcohol dehydrogenase activities in the human gastric mucosa: effects of Helicobacter pylori infection, sex, age, and the part of the stomach. Alcoholism: Clinical and Experimental Research. ,vol. 25, ,(2001) , 10.1097/00000374-200106001-00008