Influence of H. pylori CagA Coupled with Alcohol Consumption on Cytokine Profiles in Men.
作者： Baoge Qu , Xinghai Han , Guangying Ren , Yiguo Jia , Yuanxun Liu
DOI: 10.1097/MD.0000000000002721
关键词:
摘要: The aim of this study was to evaluate the effect Helicobacter pylori (H pylori) cytotoxin-associated gene A (CagA) coupled with chronic alcohol ingestion on cytokine profiles.A total 215 male subjects were divided into following 4 groups: 130 H CagA-negative consumers (CagA-) (group A), 50 CagA-positive (CagA+) B), 24 nonalcohol C), and 11 D). serum CagA, C-reactive protein (CRP), interleukin (IL)-6, IL-10, E-selectin, adiponectin (ADP), tumor necrosis factor-α (TNF-α) levels measured through enzyme-linked immunosorbent assays (ELISAs).After adjusting for age mean drinking history, a multivariable linear regression analysis revealed that daily consumption, IL-6, TNF-α, ADP significantly increased increases in CagA concentrations (P = 0.008, P = 0.000, P = 0.006, respectively). IL-6 IL-10 group lower than those B (all P = 0.000). Furthermore, groups C D P = 0.000), E-selectin higher (P = 0.000). (P = 0.000), (P = 0.000 P = 0.005, Finally, TNF-α B, C, (P = 0.005).In conclusion, may result several inflammatory markers both consumers. However, positivity does not significant changes profiles.
growkudos.com参考文章(39)
Kowalski M, Helicobacter pylori (H. pylori) infection in coronary artery disease: influence of H. pylori eradication on coronary artery lumen after percutaneous transluminal coronary angioplasty. The detection of H. pylori specific DNA in human coronary atherosclerotic plaque. Journal of Physiology and Pharmacology. ,vol. 52, pp. 3- 31 ,(2001)
Baoge Qu, Jiliang Su, Zhongdong Wang, Yafei Wang, Xinghai Han, Hui Wang, Yuanxun Liu, Yiguo Jia, Jindun Pan, Guangying Ren, Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion PLOS ONE. ,vol. 10, pp. e0129352- ,(2015) , 10.1371/JOURNAL.PONE.0129352
Yousef Rasmi, Sina Raeisi, Mir H. Seyyed Mohammadzad, Association of Inflammation and Cytotoxin-Associated Gene A Positive Strains of Helicobacter Pylori in Cardiac Syndrome X Helicobacter. ,vol. 17, pp. 116- 120 ,(2012) , 10.1111/J.1523-5378.2011.00923.X
Jingtong Wang, Michelle Court, Anthony H.T Jeremy, Mohamed A Aboshkiwa, Philip A Robinson, Jean E Crabtree, Infection of Mongolian gerbils with Chinese Helicobacter pylori strains. Fems Immunology and Medical Microbiology. ,vol. 36, pp. 207- 213 ,(2003) , 10.1016/S0928-8244(02)00464-9
CB Jackson, LM Judd, TR Menheniott, I Kronborg, C Dow, ND Yeomans, A Boussioutas, L Robb, AS Giraud, Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression. The Journal of Pathology. ,vol. 213, pp. 140- 151 ,(2007) , 10.1002/PATH.2218
Stanislaw J. Konturek, Peter C. Konturek, W. Bielanski, Elzbieta Karczewska, Monika Zuchowicz, Artur Hartwich, Jens F. Rehfeld, Jens P. Goetze, Eckhart G. Hahn, Serum progastrin and its products, gastric acid secretion and serum pepsinogen I in gastric cancer. Digestion. ,vol. 68, pp. 169- 177 ,(2003) , 10.1159/000075553
H. Brenner, D. Rothenbacher, G. Bode, G. Adler, Inverse Graded Relation between Alcohol Consumption and Active Infection with Hellcobacter pylori American Journal of Epidemiology. ,vol. 149, pp. 571- 576 ,(1999) , 10.1093/OXFORDJOURNALS.AJE.A009854
Céline Audibert, Blandine Janvier, Bernadette Grignon, Laurence Salaüna, Christophe Burucoa, Jean-Claude Lecron, Jean-Louis Fauchère, Correlation between IL-8 induction, cagA status and vacA genotypes in 153 French Helicobacter pylori isolates. Research in Microbiology. ,vol. 151, pp. 191- 200 ,(2000) , 10.1016/S0923-2508(00)00139-X
Don A Sibley, Natalia Osna, Charles Kusynski, Linda Wilkie, Thomas R Jerrells, Alcohol consumption is associated with alterations in macrophage responses to interferon-γ and infection by Salmonella typhimurium FEMS Immunology and Medical Microbiology. ,vol. 32, pp. 73- 83 ,(2001) , 10.1016/S0928-8244(01)00266-8
Miriam Maraslioglu, Elsie Oppermann, Carolin Blattner, Roxane Weber, Dirk Henrich, Christian Jobin, Elke Schleucher, Ingo Marzi, Mark Lehnert, Chronic ethanol feeding modulates inflammatory mediators, activation of nuclear factor-κB, and responsiveness to endotoxin in murine Kupffer cells and circulating leukocytes. Mediators of Inflammation. ,vol. 2014, pp. 808695- 808695 ,(2014) , 10.1155/2014/808695