Clinical Manifestations of Persistent Smear Positive and Culture Negative Sputum Tests 5 Months after First-Line Anti-Tuberculous Chemotherapy

摘要: Background: It is not known with certainty whether patients persistently positive sputum smear results who have also had negative culture require prolongation of treatment for tuberculosis in order to avoid an increased risk eventual relapse. The purpose the present study was retrospectively describe characteristics and evaluate appropriate duration these patients. Methods: Sixty 69 tests at 5 months after first line anti-tuberculous chemotherapy from 2002 2003 were analyzed. Exclusion criteria included incomplete or resistance rifampicin two additional antibiotics, as determined by a drug susceptibility test (DST). Results: Smear conversion subjects observed treatment, months. relapse rates 3.8, 10.0, 25.8% 1, 2, years anti-tuberculosis chemotherapy, respectively. significantly affected series factors such age, sex, presence diabetes, examination 2 previous history, chest radiograph, (P>0.05). Conclusion: Regimen change required persistent but fifth month antituberculous treatment. However, further will be needed clarify high rate this specific group