The significance of the persistent presence of acid-fast bacilli in sputum smears in pulmonary tuberculosis.
作者： Mohamed S. Al-Moamary , William Black , Elaine Bessuille , R. Kevin Elwood , Sverre Vedal
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摘要: Study objectives Identification of acid-fast bacilli (AFB) in the sputum smear at completion tuberculosis therapy is some settings considered evidence treatment failure. However, patients with pulmonary (TB) will have positive results negative culture end therapy. The this study were to estimate prevalence persisting TB and identify characteristics that distinguish persistently who also had from identified as failures. Design A population-based, historical cohort nested case control study. Setting British Columbia Division Tuberculosis Control central registry. Patients All 428 culture-proven over 7 years was for AFB. Methods Review laboratory data all patients, well clinical a subset 30 beyond 20 weeks. Results Sputum smears AFB 205 (48%) 4 weeks, (7%) 12 (3%) 36 Of 23 (77%) (23%) ( ie , they failures). failures more localized disease shown on chest radiographs, less radiographic improvement follow-up, higher drug resistance, compliant medications than results. No subject result relapsed 6- 48-month observation period. Conclusion developed countries likely be associated
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