Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer.

摘要: Controversy surrounds neutrophil function in cancer because neutrophils were shown to provide both pro- and antitumor functions. We identified a heterogeneous subset of low-density (LDNs) that appear transiently self-resolving inflammation but accumulate continuously with progression. LDNs display impaired immunosuppressive properties, characteristics are stark contrast those mature, high-density (HDNs). consist immature myeloid-derived suppressor cells (MDSCs) mature derived from HDNs TGF-β-dependent mechanism. Our findings identify three distinct populations circulating challenge the concept have limited plasticity. Furthermore, our mechanistic explanation mitigate controversy surrounding cancer.