Refractory Periodontitis Associated With Abnormal Polymorphonuclear Leukocyte Phagocytosis and Cigarette Smoking
作者： Gordon D. MacFarlane , Mark C. Herzberg , Larry F. Wolff , Nancy A. Hardie
DOI: 10.1902/JOP.1992.63.11.908
关键词:
摘要: To learn if refractory periodontitis may be associated with defects in peripheral blood polymorphonuclear leukocyte (PMN) function, phagocytosis and chemotaxis were analyzed 31 otherwise healthy patients 12 unaffected controls. When compared to controls, no chemotactic 10 nM f-Met-Leu-Phe (fMLP) detected. In contrast, was significantly impaired (P < 0.001). The mean rates of adhesion ingestion opsonized Staphylococcus aureus by PMNs 7.1 +/- 1.7 (+/- SD) 1.4 0.5 bacteria/100 PMNs/minute respectively for patients, 11.0 2.4 3.1 0.6 unaffected, While the quality oral hygiene access dental care high, a retrospective search environmental variables showed that 90% (28 31) smokers. frequency smokers is particularly striking, since only 21% adults Minnesota use tobacco regularly. These data suggest there strong association between PMN defect periodontitis. Furthermore, these studies contribute this association.
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