Sensitive spectrophotometric determination of amlodipine and felodipine using iron(III) and ferricyanide.

摘要: Abstract A simple, accurate, sensitive and economical procedure for the estimation of amlodipine besylate felodipine, both in pure form formulations has been developed. The method is based on reduction iron(III) by studied drugs acid medium subsequent interaction iron(II) with ferricyanide to Prussian blue. product exhibits absorption maximum at 760 nm cases. Beer's law obeyed concentration ranges 5.0–15.0 1.5–5.0 μg/ml, respectively. molar absorptivities are 1.76×10 4 4.24×10 l/mol cm. corresponding Sandell sensitivities 23.18 9.06 ng/cm 2 . limits detection as well quantification reported. Seven replicate analyses solutions containing three different concentrations each drug were carried out percent error RSD values have proposed was applied determination these pharmaceutical results demonstrate that equally accurate precise official methods found from t - F -values. reliability established recovery studies using standard-addition technique.