Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcome of 217 patients

摘要: BACKGROUND Primary adenocarcinoma of the small bowel is a rare neoplasm, and to authors' knowledge, few studies date have addressed topic. METHODS In current study, records 217 patients with were reviewed retrospectively for presentation, prognostic factors, treatment modalities, outcome. RESULTS The median age was 55 years there 133 (61%) males. Tumors originated in duodenum 113 (52%) patients, jejunum 54 (25%) ileum 28 (13%) nonspecified sites 22 (10%) patients. Patients proximal tumors diagnosed most part using endoscopy (i.e., 46 108 [43%]), whereas laparotomy enabled diagnosis 16 (57%) distal tumors. Based on TNM staging, 9 (4%) had Stage I disease, 43 (20%) II 86 (39%) III 75 (35%) IV disease. The liver common site metastasis 44 (59%) Cancer-directed surgery performed 146 (67 %) including Whipple procedure 36 (17%). overall survival time 20 months. 5-year rate 26%. surgery, early-stage lymph node involvement ratio significantly associated by univariate analysis. However, only cancer-directed independent predictors multivariate analysis (adjusted = 0.14; 95% confidence interval [95% CI], 0.04–0.46; P 0.001 adjusted 0.25; CI, 0.12–0.53; < 0.001, respectively). CONCLUSIONS Performing an oncologic resulted best outcome nonmetastatic Because high morbidity mortality primary centers, these should be referred tertiary center adequate treatment. Cancer 2004. © 2004 American Society.