A prospective study of body size and breast cancer in black women.

摘要: The relation of body mass index (BMI) and weight gain to breast cancer risk is complex, little information available on Black women, among whom the prevalence obesity high. We assessed BMI in prospective data from Women's Health Study. In 1995, 59,000 African American women enrolled Study by completing mailed questionnaires. Data anthropometric factors were obtained at baseline every 2 years afterwards. 10 follow-up, 1,062 incident cases occurred. Incidence rate ratios (IRR) computed multivariable Cox proportional hazards regression. age 18 ≥25 relative <20 was associated with a reduced both premenopausal (IRR, 0.68; 95% confidence interval, 0.46-0.98) postmenopausal 0.53; 0.35-0.81). There an inverse association current but no cancer, either overall or never-users hormone therapy. Weight not risk. analyses restricted cancers that estrogen progesterone receptor positive, IRRs for elevated statistically significant. findings indicate being overweight women. Understanding reasons may help elucidate pathways through which adolescent exposures influence lack receptor-negative tumors partially explain why incidence older high other ethnic groups spite (Cancer Epidemiol Biomarkers Prev 2007;16(9):1795–802)