Orthostatic hypotension does not increase cardiovascular risk in the elderly at a population level.

摘要: Background The general belief that orthostatic hypotension (OH) predisposes to cardiovascular events is based on sparse and contradictory data, rarely derived from population studies. Methods A total of 1,016 men women aged ≥65 years was studied in a 12-year epidemiological population-based study. Cardiovascular were detected subjects with without OH (blood pressure (BP) decrease ≥20mm Hg for systolic or ≥10mm diastolic), Cox analysis performed including as an independent variable. Results In univariate analysis, coronary (20.2% vs. 13.1%, P = 0.05), cerebrovascular (13.1% 8.4%, heart failure (HF) 13.8%, 0.03) apparently more incidental than those OH. Nevertheless, after adjusting age, gender, BP confounders, did not act predictor (relative risk 1.33, 95% confidence interval (CI), 0.78-2.2, 1.25, CI 0.82-1.88, HF 1.07, 0.71-1.62, arrhythmias 0.82, 0.40-1.37, syncope 0.58, 0.13-2.71). Conclusions Although seems be coronary, cerebrovascular, events, no predictive role found models include biological confounders. Independent the cause OH, age BP, which are positively associated fully explain greater incidence observed